Drug interactions
Captopril-hydrochlorothiazide + Sirolimus
Severity: Major
Captopril-hydrochlorothiazide and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of mTOR inhibitors such as sirolimus and ACE inhibitors increases the risk of angioedema. Reactions can be serious if the airway is involved.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Sirolimus belongs to Miscellaneous.
Why it happens
Additive impairment of bradykinin degradation, as mTOR inhibitors reduce DPP-4 activity and ACE inhibitors block ACE.
What to do
Consider an alternative antihypertensive such as a calcium channel blocker when possible. If combined, educate patients to seek urgent care for facial or tongue swelling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Sirolimus?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of mTOR inhibitors such as sirolimus and ACE inhibitors increases the risk of angioedema. Reactions can be serious if the airway is involved.
How serious is the interaction between Captopril-hydrochlorothiazide and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antihypertensive such as a calcium channel blocker when possible. If combined, educate patients to seek urgent care for facial or tongue swelling.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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