Drug interactions
Captopril-hydrochlorothiazide + Succinylcholine
Severity: Moderate
Captopril-hydrochlorothiazide and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Succinylcholine can transiently raise serum potassium, while thiazide-induced hypokalemia or electrolyte disturbance may alter neuromuscular blockade and arrhythmia risk. Clinical significance is uncertain and mostly relevant perioperatively.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Opposing potassium effects; thiazide electrolyte disturbances may also modify neuromuscular blockade.
What to do
Check serum potassium and electrolytes before surgery and correct abnormalities. Monitor ECG and neuromuscular function during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Succinylcholine
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Succinylcholine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Succinylcholine can transiently raise serum potassium, while thiazide-induced hypokalemia or electrolyte disturbance may alter neuromuscular blockade and arrhythmia risk. Clinical significance is uncertain and mostly relevant perioperatively.
How serious is the interaction between Captopril-hydrochlorothiazide and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and electrolytes before surgery and correct abnormalities. Monitor ECG and neuromuscular function during anesthesia.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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