Drug interactions
Captopril-hydrochlorothiazide + Torsemide
Severity: Moderate
Captopril-hydrochlorothiazide and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to an ACE inhibitor and thiazide regimen produces strong diuresis and sequential nephron blockade. This can cause marked hypotension, particularly after the first doses, and may cause acute kidney injury in volume-depleted patients. Electrolyte disturbances are also more likely.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects: diuretic-induced volume depletion combined with ACE inhibitor loss of angiotensin II-mediated efferent arteriolar tone.
What to do
Monitor blood pressure, renal function and electrolytes, especially at initiation or dose changes. Consider lowering the diuretic dose if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Torsemide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Torsemide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to an ACE inhibitor and thiazide regimen produces strong diuresis and sequential nephron blockade. This can cause marked hypotension, particularly after the first doses, and may cause acute kidney injury in volume-depleted patients. Electrolyte disturbances are also more likely.
How serious is the interaction between Captopril-hydrochlorothiazide and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, especially at initiation or dose changes. Consider lowering the diuretic dose if the patient is volume depleted.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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