Drug interactions
Carbachol + Clomipramine
Severity: Minor
Carbachol and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist, whereas clomipramine has strong antimuscarinic activity. Clomipramine may reduce the effect of carbachol, although with ophthalmic use systemic exposure is small.
What this interaction means in plain words
Carbachol and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Clomipramine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between muscarinic agonism and antimuscarinic blockade.
What to do
Monitor for reduced therapeutic response to carbachol, such as inadequate miosis or intraocular pressure control. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Clomipramine?
MediHelp rates the interaction as minor. Carbachol and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a cholinergic agonist, whereas clomipramine has strong antimuscarinic activity. Clomipramine may reduce the effect of carbachol, although with ophthalmic use systemic exposure is small.
How serious is the interaction between Carbachol and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic response to carbachol, such as inadequate miosis or intraocular pressure control. No routine dose change is needed.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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