Drug interactions
Carbachol + Glycopyrronium
Severity: Moderate
Carbachol and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a cholinergic agonist and glycopyrronium is a muscarinic antagonist, so they oppose each other's effects. The result is reduced effectiveness of carbachol, particularly on muscarinic targets such as the pupil, bladder and gut.
What this interaction means in plain words
Carbachol and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbachol belongs to Miscellaneous; Glycopyrronium belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid combining when the cholinergic effect of carbachol is needed; if combined, monitor therapeutic response and adjust doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
- Amoxapine + Glycopyrronium Moderate
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Glycopyrronium?
MediHelp rates the interaction as moderate. Carbachol and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbachol is a cholinergic agonist and glycopyrronium is a muscarinic antagonist, so they oppose each other's effects. The result is reduced effectiveness of carbachol, particularly on muscarinic targets such as the pupil, bladder and gut.
How serious is the interaction between Carbachol and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when the cholinergic effect of carbachol is needed; if combined, monitor therapeutic response and adjust doses.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Glycopyrronium page.
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