Drug interactions
Carbachol + Ipratropium
Severity: Minor
Carbachol and Ipratropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a muscarinic agonist and ipratropium is a muscarinic antagonist, so they can oppose one another at the same receptors. Reduced effect of carbachol, for example miosis or reduced intraocular pressure, is possible, but with inhaled ipratropium systemic exposure is low.
What this interaction means in plain words
Carbachol and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Ipratropium belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor the response to carbachol, such as intraocular pressure when it is used for glaucoma. Adjust therapy only if there is a loss of effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ipratropium
- Aclidinium + Ipratropium Moderate
- Benztropine + Ipratropium Moderate
- Bethanechol + Ipratropium Moderate
- Cevimeline + Ipratropium Moderate
- Chlorpromazine + Ipratropium Moderate
- Clomipramine + Ipratropium Moderate
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Ipratropium?
MediHelp rates the interaction as minor. Carbachol and Ipratropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a muscarinic agonist and ipratropium is a muscarinic antagonist, so they can oppose one another at the same receptors. Reduced effect of carbachol, for example miosis or reduced intraocular pressure, is possible, but with inhaled ipratropium systemic exposure is low.
How serious is the interaction between Carbachol and Ipratropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the response to carbachol, such as intraocular pressure when it is used for glaucoma. Adjust therapy only if there is a loss of effect.
What other medicines interact with Ipratropium?
MediHelp also lists interactions of Ipratropium with, for example, Aclidinium, Benztropine, Bethanechol. The full list is on the Ipratropium page.
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