Drug interactions
Carbachol + Solifenacin
Severity: Minor
Carbachol and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbachol is a muscarinic agonist, whereas solifenacin blocks muscarinic receptors, so each can reduce the effect of the other. Systemic exposure from ophthalmic carbachol is low, so the practical impact is generally minor.
What this interaction means in plain words
Carbachol and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbachol belongs to Miscellaneous; Solifenacin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
No specific action is needed; monitor for reduced effect of either drug if carbachol is given systemically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Other interactions of Carbachol
- Atropine + Carbachol Moderate
- Bethanechol + Carbachol Moderate
- Carbachol + Darifenacin Moderate
- Carbachol + Dicyclomine Moderate
- Carbachol + Donepezil Moderate
- Carbachol + Flavoxate Moderate
Frequently asked questions
Can I take Carbachol with Solifenacin?
MediHelp rates the interaction as minor. Carbachol and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbachol is a muscarinic agonist, whereas solifenacin blocks muscarinic receptors, so each can reduce the effect of the other. Systemic exposure from ophthalmic carbachol is low, so the practical impact is generally minor.
How serious is the interaction between Carbachol and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; monitor for reduced effect of either drug if carbachol is given systemically.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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