Drug interactions
Carbamazepine + Celecoxib
Severity: Minor
Carbamazepine and Celecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong enzyme inducer and may lower celecoxib concentrations, reducing its effect. The magnitude is not well characterized.
What this interaction means in plain words
Carbamazepine and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Celecoxib belongs to Musculoskeletal.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C9, increasing celecoxib clearance.
What to do
Monitor for reduced celecoxib effect and titrate within the labeled dose range if required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Celecoxib?
MediHelp rates the interaction as minor. Carbamazepine and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine is a strong enzyme inducer and may lower celecoxib concentrations, reducing its effect. The magnitude is not well characterized.
How serious is the interaction between Carbamazepine and Celecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced celecoxib effect and titrate within the labeled dose range if required.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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