Drug interactions
Carbamazepine + Cilostazol
Severity: Moderate
Carbamazepine and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and may reduce cilostazol exposure, which could reduce its therapeutic effect in claudication.
What this interaction means in plain words
Carbamazepine and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Cilostazol belongs to Cardiovascular.
Why it happens
CYP3A4 induction increases cilostazol metabolism.
What to do
Monitor for reduced claudication relief and consider alternatives if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Cilostazol?
MediHelp rates the interaction as moderate. Carbamazepine and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and may reduce cilostazol exposure, which could reduce its therapeutic effect in claudication.
How serious is the interaction between Carbamazepine and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced claudication relief and consider alternatives if efficacy is lost.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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