Drug interactions
Carbamazepine + Cisatracurium
Severity: Minor
Carbamazepine and Cisatracurium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic carbamazepine therapy can reduce the effect and shorten the duration of nondepolarizing neuromuscular blockers. Patients may need higher cisatracurium doses and recover faster.
What this interaction means in plain words
Carbamazepine and Cisatracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Cisatracurium belongs to Musculoskeletal.
Why it happens
Chronic anticonvulsant exposure is thought to cause resistance via receptor upregulation and possibly altered drug disposition.
What to do
Monitor neuromuscular blockade with train-of-four and increase cisatracurium dosing as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cisatracurium
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Cisatracurium?
MediHelp rates the interaction as minor. Carbamazepine and Cisatracurium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic carbamazepine therapy can reduce the effect and shorten the duration of nondepolarizing neuromuscular blockers. Patients may need higher cisatracurium doses and recover faster.
How serious is the interaction between Carbamazepine and Cisatracurium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four and increase cisatracurium dosing as needed.
What other medicines interact with Cisatracurium?
MediHelp also lists interactions of Cisatracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Cisatracurium page.
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