Drug interactions
Carbamazepine + Dexlansoprazole
Severity: Moderate
Carbamazepine and Dexlansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and can lower dexlansoprazole exposure, possibly reducing acid suppression. Carbamazepine levels are not expected to change meaningfully.
What this interaction means in plain words
Carbamazepine and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Carbamazepine induces CYP3A4 and CYP2C19, speeding dexlansoprazole metabolism.
What to do
Monitor for breakthrough reflux symptoms and increase the dexlansoprazole dose or choose another acid suppressant if control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Dexlansoprazole?
MediHelp rates the interaction as moderate. Carbamazepine and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a strong CYP3A4 inducer and can lower dexlansoprazole exposure, possibly reducing acid suppression. Carbamazepine levels are not expected to change meaningfully.
How serious is the interaction between Carbamazepine and Dexlansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough reflux symptoms and increase the dexlansoprazole dose or choose another acid suppressant if control is poor.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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