Drug interactions
Carbamazepine + Dutasteride-tamsulosin
Severity: Moderate
Carbamazepine and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can reduce plasma concentrations of tamsulosin and dutasteride. Loss of symptom control may occur.
What this interaction means in plain words
Carbamazepine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
CYP3A4 induction by carbamazepine increases the clearance of tamsulosin and dutasteride.
What to do
Monitor for reduced response in urinary symptoms and adjust therapy if needed. Consider an alternative if efficacy is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Carbamazepine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can reduce plasma concentrations of tamsulosin and dutasteride. Loss of symptom control may occur.
How serious is the interaction between Carbamazepine and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response in urinary symptoms and adjust therapy if needed. Consider an alternative if efficacy is inadequate.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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