Drug interactions
Carbamazepine + Eltrombopag
Severity: Moderate
Carbamazepine and Eltrombopag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is an enzyme inducer and may lower eltrombopag exposure, which could reduce the platelet response. The effect is predicted from the induction of eltrombopag's metabolic pathways.
What this interaction means in plain words
Carbamazepine and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Eltrombopag belongs to Miscellaneous.
Why it happens
Carbamazepine induces hepatic enzymes (including CYP1A2 and CYP2C9) and UGT involved in eltrombopag clearance.
What to do
Monitor platelet counts when carbamazepine is started or stopped and increase the eltrombopag dose if the response is inadequate. Re-evaluate the dose after carbamazepine is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Carbamazepine with Eltrombopag?
MediHelp rates the interaction as moderate. Carbamazepine and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is an enzyme inducer and may lower eltrombopag exposure, which could reduce the platelet response. The effect is predicted from the induction of eltrombopag's metabolic pathways.
How serious is the interaction between Carbamazepine and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts when carbamazepine is started or stopped and increase the eltrombopag dose if the response is inadequate. Re-evaluate the dose after carbamazepine is withdrawn.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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