Drug interactions
Carbamazepine + Enalapril-hydrochlorothiazide
Severity: Moderate
Carbamazepine and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both carbamazepine and hydrochlorothiazide can lower serum sodium. Used together they may produce clinically significant hyponatremia, with confusion, headache, seizures or falls, especially in older adults.
What this interaction means in plain words
Carbamazepine and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hyponatremia: carbamazepine enhances renal antidiuretic hormone action while thiazides increase renal sodium loss.
What to do
Check serum sodium at baseline and periodically, especially after starting or increasing either drug. Stop or change the diuretic if sodium falls significantly or symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Carbamazepine and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both carbamazepine and hydrochlorothiazide can lower serum sodium. Used together they may produce clinically significant hyponatremia, with confusion, headache, seizures or falls, especially in older adults.
How serious is the interaction between Carbamazepine and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, especially after starting or increasing either drug. Stop or change the diuretic if sodium falls significantly or symptoms appear.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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