Drug interactions
Carbamazepine + Fluticasone
Severity: Minor
Carbamazepine and Fluticasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and may lower systemic exposure to fluticasone. Effect on local lung activity is probably small, but systemic exposure is reduced and control may be affected.
What this interaction means in plain words
Carbamazepine and Fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Fluticasone belongs to Respiratory.
Why it happens
Induction of CYP3A4 metabolism of fluticasone by carbamazepine.
What to do
No routine dose change is needed; reassess asthma or rhinitis control if symptoms worsen after carbamazepine is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Fluticasone?
MediHelp rates the interaction as minor. Carbamazepine and Fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbamazepine induces CYP3A4 and may lower systemic exposure to fluticasone. Effect on local lung activity is probably small, but systemic exposure is reduced and control may be affected.
How serious is the interaction between Carbamazepine and Fluticasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; reassess asthma or rhinitis control if symptoms worsen after carbamazepine is started.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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