Drug interactions
Carbamazepine + Fosinopril-hydrochlorothiazide
Severity: Moderate
Carbamazepine and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both carbamazepine and hydrochlorothiazide can lower serum sodium, so using them together raises the risk of clinically significant hyponatremia. Symptoms range from nausea and confusion to seizures, and older patients are especially vulnerable.
What this interaction means in plain words
Carbamazepine and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive sodium loss and impaired water excretion, from thiazide-induced renal sodium wasting and carbamazepine-related antidiuretic hormone effects.
What to do
Check serum sodium at baseline and periodically, particularly after starting or changing doses. Reduce or change one agent if sodium falls or symptoms of hyponatremia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Carbamazepine and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both carbamazepine and hydrochlorothiazide can lower serum sodium, so using them together raises the risk of clinically significant hyponatremia. Symptoms range from nausea and confusion to seizures, and older patients are especially vulnerable.
How serious is the interaction between Carbamazepine and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and periodically, particularly after starting or changing doses. Reduce or change one agent if sodium falls or symptoms of hyponatremia appear.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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