Drug interactions
Carbamazepine + Nicardipine
Severity: Moderate
Carbamazepine and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can substantially reduce nicardipine concentrations, causing reduced antihypertensive or antianginal effect. Nicardipine may in turn modestly raise carbamazepine levels.
What this interaction means in plain words
Carbamazepine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Nicardipine belongs to Cardiovascular.
Why it happens
Carbamazepine induces CYP3A4, increasing nicardipine metabolism.
What to do
Monitor blood pressure and titrate nicardipine upward, or choose an antihypertensive less affected by induction. Check carbamazepine concentrations and signs of toxicity if nicardipine is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Nicardipine?
MediHelp rates the interaction as moderate. Carbamazepine and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can substantially reduce nicardipine concentrations, causing reduced antihypertensive or antianginal effect. Nicardipine may in turn modestly raise carbamazepine levels.
How serious is the interaction between Carbamazepine and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and titrate nicardipine upward, or choose an antihypertensive less affected by induction. Check carbamazepine concentrations and signs of toxicity if nicardipine is started.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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