Drug interactions
Carbamazepine + Oliceridine
Severity: Moderate
Carbamazepine and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower oliceridine exposure and reduce analgesia. If carbamazepine is later stopped, oliceridine levels may rise and cause respiratory depression.
What this interaction means in plain words
Carbamazepine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Carbamazepine induces CYP3A4, increasing oliceridine metabolism.
What to do
Titrate oliceridine to analgesic effect and monitor for withdrawal or inadequate pain control. If carbamazepine is stopped, reduce the oliceridine dose and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Carbamazepine with Oliceridine?
MediHelp rates the interaction as moderate. Carbamazepine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can lower oliceridine exposure and reduce analgesia. If carbamazepine is later stopped, oliceridine levels may rise and cause respiratory depression.
How serious is the interaction between Carbamazepine and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine to analgesic effect and monitor for withdrawal or inadequate pain control. If carbamazepine is stopped, reduce the oliceridine dose and monitor for sedation and respiratory depression.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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