Drug interactions
Carbamazepine + Pexidartinib
Severity: Major
Carbamazepine and Pexidartinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower pexidartinib exposure, and pexidartinib may in turn lower carbamazepine concentrations. Both drugs are hepatotoxic, so combined use adds liver injury risk.
What this interaction means in plain words
Carbamazepine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4 metabolism of pexidartinib, and the effect of pexidartinib on carbamazepine is also via CYP3A4 induction, together with additive hepatotoxicity.
What to do
Avoid the combination and use a non-inducing, non-hepatotoxic anticonvulsant. If unavoidable, monitor liver tests and carbamazepine levels regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Carbamazepine with Pexidartinib?
MediHelp rates the interaction as major. Carbamazepine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine can lower pexidartinib exposure, and pexidartinib may in turn lower carbamazepine concentrations. Both drugs are hepatotoxic, so combined use adds liver injury risk.
How serious is the interaction between Carbamazepine and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing, non-hepatotoxic anticonvulsant. If unavoidable, monitor liver tests and carbamazepine levels regularly.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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