Drug interactions
Carbamazepine + Tinidazole
Severity: Moderate
Carbamazepine and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is a strong CYP3A4 inducer and can speed up the clearance of tinidazole, lowering its concentrations. This may reduce the effectiveness of tinidazole, especially in infections that require adequate drug exposure.
What this interaction means in plain words
Carbamazepine and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Tinidazole belongs to Anti Parasitic.
Why it happens
Carbamazepine induces CYP3A4, increasing hepatic and intestinal metabolism of tinidazole.
What to do
Monitor clinical response to tinidazole and consider an alternative or a longer course if the infection does not respond. Consider alternative antimicrobial therapy if treatment failure is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Tinidazole?
MediHelp rates the interaction as moderate. Carbamazepine and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine is a strong CYP3A4 inducer and can speed up the clearance of tinidazole, lowering its concentrations. This may reduce the effectiveness of tinidazole, especially in infections that require adequate drug exposure.
How serious is the interaction between Carbamazepine and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tinidazole and consider an alternative or a longer course if the infection does not respond. Consider alternative antimicrobial therapy if treatment failure is suspected.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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