Drug interactions
Carbamazepine + Ustekinumab
Severity: Minor
Carbamazepine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 expression, and IL-12/23 blockade may reverse this, potentially lowering levels of CYP substrates such as carbamazepine. The effect is theoretical but relevant for narrow therapeutic index drugs.
What this interaction means in plain words
Carbamazepine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbamazepine belongs to Central Nervous System; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Cytokine modulation by ustekinumab may normalize suppressed CYP450 enzyme expression.
What to do
Consider checking carbamazepine concentrations when ustekinumab is started or stopped, and adjust the dose according to levels and response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Ustekinumab?
MediHelp rates the interaction as minor. Carbamazepine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 expression, and IL-12/23 blockade may reverse this, potentially lowering levels of CYP substrates such as carbamazepine. The effect is theoretical but relevant for narrow therapeutic index drugs.
How serious is the interaction between Carbamazepine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider checking carbamazepine concentrations when ustekinumab is started or stopped, and adjust the dose according to levels and response.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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