Drug interactions
Carbamazepine + Ziprasidone
Severity: Moderate
Carbamazepine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and can lower ziprasidone concentrations, potentially reducing antipsychotic effectiveness. Labeling reports a moderate reduction in ziprasidone exposure with carbamazepine.
What this interaction means in plain words
Carbamazepine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by carbamazepine increases ziprasidone metabolism.
What to do
Monitor for loss of antipsychotic response when carbamazepine is started and consider increasing the ziprasidone dose. Reassess the dose if carbamazepine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Ziprasidone?
MediHelp rates the interaction as moderate. Carbamazepine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and can lower ziprasidone concentrations, potentially reducing antipsychotic effectiveness. Labeling reports a moderate reduction in ziprasidone exposure with carbamazepine.
How serious is the interaction between Carbamazepine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antipsychotic response when carbamazepine is started and consider increasing the ziprasidone dose. Reassess the dose if carbamazepine is stopped.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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