Drug interactions
Carbidopa + Hydrochlorothiazide-lisinopril
Severity: Minor
Carbidopa and Hydrochlorothiazide-lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa given with levodopa can add to the blood pressure lowering of antihypertensives, causing orthostatic hypotension. The effect is largely due to levodopa, with carbidopa alone having little effect.
What this interaction means in plain words
Carbidopa and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa belongs to Central Nervous System; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effect, mainly from levodopa-derived dopamine.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing levodopa/carbidopa, and reduce the antihypertensive dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as minor. Carbidopa and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbidopa given with levodopa can add to the blood pressure lowering of antihypertensives, causing orthostatic hypotension. The effect is largely due to levodopa, with carbidopa alone having little effect.
How serious is the interaction between Carbidopa and Hydrochlorothiazide-lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing levodopa/carbidopa, and reduce the antihypertensive dose if needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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