Drug interactions
Carbidopa-entacapone-levodopa + Prochlorperazine
Severity: Major
Carbidopa-entacapone-levodopa and Prochlorperazine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine blocks central dopamine receptors and can reduce levodopa effect, worsening Parkinson symptoms. It is often given as an antiemetic, so the interaction is easily overlooked.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through D2 receptor blockade.
What to do
Use domperidone (where available) or ondansetron as antiemetic instead. Avoid prochlorperazine in Parkinson disease.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Almus Migraine Relief 3mg Buccal Tablets - SmPC sections 4.3/4.5 (names the partner; "Prochlorperazine opposes the effects of levodopa.") — electronic medicines compendium (UK SmPC)
Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Prochlorperazine?
MediHelp rates the interaction as major. Carbidopa-entacapone-levodopa and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prochlorperazine blocks central dopamine receptors and can reduce levodopa effect, worsening Parkinson symptoms. It is often given as an antiemetic, so the interaction is easily overlooked.
How serious is the interaction between Carbidopa-entacapone-levodopa and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use domperidone (where available) or ondansetron as antiemetic instead. Avoid prochlorperazine in Parkinson disease.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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