Drug interactions
Carbidopa-levodopa + Metolazone
Severity: Moderate
Carbidopa-levodopa and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure, and metolazone's potent diuretic action adds to volume depletion. Orthostatic hypotension and falls are possible.
What this interaction means in plain words
Carbidopa-levodopa and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-levodopa belongs to Central Nervous System; Metolazone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotension from levodopa's vasodilatory effects and diuretic-induced volume depletion.
What to do
Monitor orthostatic blood pressure and electrolytes when starting or changing either drug. Reduce the metolazone dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-levodopa
- Carbidopa-levodopa + Isocarboxazid Contraindicated
- Carbidopa-levodopa + Phenelzine Contraindicated
- Carbidopa-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-levodopa Major
- Asenapine + Carbidopa-levodopa Major
Other interactions of Metolazone
Frequently asked questions
Can I take Carbidopa-levodopa with Metolazone?
MediHelp rates the interaction as moderate. Carbidopa-levodopa and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure, and metolazone's potent diuretic action adds to volume depletion. Orthostatic hypotension and falls are possible.
How serious is the interaction between Carbidopa-levodopa and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and electrolytes when starting or changing either drug. Reduce the metolazone dose if symptomatic hypotension develops.
What other medicines interact with Carbidopa-levodopa?
MediHelp also lists interactions of Carbidopa-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-levodopa page.
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