Drug interactions
Carbinoxamine + Fluphenazine
Severity: Moderate
Carbinoxamine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine and fluphenazine is a sedating antipsychotic with anticholinergic activity. Together they can increase drowsiness, confusion and anticholinergic effects such as dry mouth, constipation and urinary retention, particularly in older adults.
What this interaction means in plain words
Carbinoxamine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic effects, and consider a non-sedating antihistamine if appropriate. Warn patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Fluphenazine?
MediHelp rates the interaction as moderate. Carbinoxamine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine and fluphenazine is a sedating antipsychotic with anticholinergic activity. Together they can increase drowsiness, confusion and anticholinergic effects such as dry mouth, constipation and urinary retention, particularly in older adults.
How serious is the interaction between Carbinoxamine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, and consider a non-sedating antihistamine if appropriate. Warn patients about driving and operating machinery.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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