Drug interactions
Carbinoxamine + Hydroxyzine
Severity: Moderate
Carbinoxamine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are first-generation antihistamines with sedating and anticholinergic properties, so combined use can cause excessive drowsiness, dry mouth, urinary retention and confusion. It is effectively duplicate therapy and older adults and children are especially vulnerable.
What this interaction means in plain words
Carbinoxamine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Hydroxyzine belongs to Respiratory.
Why it happens
Additive histamine H1 blockade with CNS depression and antimuscarinic effects.
What to do
Avoid using two sedating antihistamines together, and choose one agent or a non-sedating alternative. Monitor for sedation and anticholinergic effects if both are unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Hydroxyzine?
MediHelp rates the interaction as moderate. Carbinoxamine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are first-generation antihistamines with sedating and anticholinergic properties, so combined use can cause excessive drowsiness, dry mouth, urinary retention and confusion. It is effectively duplicate therapy and older adults and children are especially vulnerable.
How serious is the interaction between Carbinoxamine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two sedating antihistamines together, and choose one agent or a non-sedating alternative. Monitor for sedation and anticholinergic effects if both are unavoidable.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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