Drug interactions
Carbinoxamine + Perphenazine
Severity: Moderate
Carbinoxamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating antihistamine with anticholinergic activity, which adds to the sedative and anticholinergic effects of perphenazine. This may cause marked drowsiness, dry mouth, urinary retention and confusion.
What this interaction means in plain words
Carbinoxamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbinoxamine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor for sedation and anticholinergic effects, especially in elderly patients. Consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Carbinoxamine with Perphenazine?
MediHelp rates the interaction as moderate. Carbinoxamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating antihistamine with anticholinergic activity, which adds to the sedative and anticholinergic effects of perphenazine. This may cause marked drowsiness, dry mouth, urinary retention and confusion.
How serious is the interaction between Carbinoxamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and anticholinergic effects, especially in elderly patients. Consider a non-sedating antihistamine as an alternative.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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