Drug interactions
Carbonyl iron + Esomeprazole
Severity: Moderate
Carbonyl iron and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron absorption depends on gastric acid, and long-term PPI use can reduce iron uptake. Iron stores may fall or iron deficiency anemia may respond poorly to oral therapy.
What this interaction means in plain words
Carbonyl iron and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces the conversion and solubility of iron salts, decreasing their absorption.
What to do
Monitor hemoglobin and ferritin in patients on long-term PPI therapy. Consider a higher dose, a different iron formulation, or IV iron if the response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Frequently asked questions
Can I take Carbonyl iron with Esomeprazole?
MediHelp rates the interaction as moderate. Carbonyl iron and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron absorption depends on gastric acid, and long-term PPI use can reduce iron uptake. Iron stores may fall or iron deficiency anemia may respond poorly to oral therapy.
How serious is the interaction between Carbonyl iron and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin in patients on long-term PPI therapy. Consider a higher dose, a different iron formulation, or IV iron if the response is poor.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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