Drug interactions
Carboplatin + Pentamidine
Severity: Moderate
Carboplatin and Pentamidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine can cause nephrotoxicity, electrolyte disturbances and dysglycemia. Together with carboplatin, renal injury is more likely, and impaired clearance can increase carboplatin toxicity.
What this interaction means in plain words
Carboplatin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carboplatin belongs to Oncology; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive nephrotoxicity.
What to do
Monitor serum creatinine, potassium, magnesium and blood counts during combined use. Dose carboplatin according to current renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carboplatin
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Carboplatin with Pentamidine?
MediHelp rates the interaction as moderate. Carboplatin and Pentamidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic pentamidine can cause nephrotoxicity, electrolyte disturbances and dysglycemia. Together with carboplatin, renal injury is more likely, and impaired clearance can increase carboplatin toxicity.
How serious is the interaction between Carboplatin and Pentamidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium, magnesium and blood counts during combined use. Dose carboplatin according to current renal function.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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