Drug interactions
Carfilzomib + Sarecycline
Severity: Minor
Carfilzomib and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline is predicted to inhibit P-glycoprotein weakly, which could slightly raise carfilzomib exposure. Oral sarecycline is used for acne, and the clinical relevance with carfilzomib is probably negligible.
What this interaction means in plain words
Carfilzomib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carfilzomib belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Sarecycline may weakly inhibit P-gp efflux, possibly raising carfilzomib concentrations.
What to do
No dose adjustment is needed; be aware of the possibility and monitor for carfilzomib toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Carfilzomib with Sarecycline?
MediHelp rates the interaction as minor. Carfilzomib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline is predicted to inhibit P-glycoprotein weakly, which could slightly raise carfilzomib exposure. Oral sarecycline is used for acne, and the clinical relevance with carfilzomib is probably negligible.
How serious is the interaction between Carfilzomib and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; be aware of the possibility and monitor for carfilzomib toxicity.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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