Drug interactions
Cariprazine + Clomipramine
Severity: Moderate
Cariprazine and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and orthostatic effects, so combined use may increase drowsiness and impaired coordination. Clomipramine may also modestly affect cariprazine exposure through its metabolic effects.
What this interaction means in plain words
Cariprazine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects.
What to do
Monitor for sedation, dizziness and orthostatic hypotension, particularly during dose changes. Counsel on driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Clomipramine?
MediHelp rates the interaction as moderate. Cariprazine and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and orthostatic effects, so combined use may increase drowsiness and impaired coordination. Clomipramine may also modestly affect cariprazine exposure through its metabolic effects.
How serious is the interaction between Cariprazine and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic hypotension, particularly during dose changes. Counsel on driving and machinery.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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