Drug interactions
Cariprazine + Dexchlorpheniramine
Severity: Moderate
Cariprazine and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine and may add to cariprazine-related drowsiness and impaired psychomotor performance. Additive anticholinergic effects are also possible.
What this interaction means in plain words
Cariprazine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-receptor antagonism and antipsychotic receptor blockade.
What to do
Counsel on additive drowsiness and avoid driving until response is known. Use a non-sedating antihistamine where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cariprazine and Dexchlorpheniramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cariprazine
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Cariprazine with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Cariprazine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexchlorpheniramine is a sedating antihistamine and may add to cariprazine-related drowsiness and impaired psychomotor performance. Additive anticholinergic effects are also possible.
How serious is the interaction between Cariprazine and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on additive drowsiness and avoid driving until response is known. Use a non-sedating antihistamine where possible.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
