Drug interactions
Cariprazine + Difelikefalin
Severity: Moderate
Cariprazine and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause dizziness, somnolence and fatigue, which may add to the sedative effects of cariprazine. Patients on hemodialysis, in whom difelikefalin is used, may be especially prone to falls.
What this interaction means in plain words
Cariprazine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depression; difelikefalin acts as a peripherally restricted kappa-opioid agonist with some central effects.
What to do
Monitor for dizziness, drowsiness and falls after starting either drug. Counsel patients on avoiding driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Cariprazine with Difelikefalin?
MediHelp rates the interaction as moderate. Cariprazine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause dizziness, somnolence and fatigue, which may add to the sedative effects of cariprazine. Patients on hemodialysis, in whom difelikefalin is used, may be especially prone to falls.
How serious is the interaction between Cariprazine and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, drowsiness and falls after starting either drug. Counsel patients on avoiding driving until the response is known.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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