Drug interactions
Cariprazine + Entacapone
Severity: Moderate
Cariprazine and Entacapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Entacapone is a COMT inhibitor given to extend the effect of levodopa, while cariprazine is a dopamine D2/D3 partial agonist antipsychotic. Their dopaminergic actions oppose each other, which may reduce the antiparkinsonian benefit or worsen psychosis. Sedation and dizziness can also add up.
What this interaction means in plain words
Cariprazine and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Entacapone belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine receptors, with possible additive sedative or orthostatic effects.
What to do
Monitor motor symptoms and psychiatric status when the combination is started or adjusted. Advise on sedation and orthostatic dizziness, and review the antipsychotic choice if parkinsonism worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Cariprazine with Entacapone?
MediHelp rates the interaction as moderate. Cariprazine and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Entacapone is a COMT inhibitor given to extend the effect of levodopa, while cariprazine is a dopamine D2/D3 partial agonist antipsychotic. Their dopaminergic actions oppose each other, which may reduce the antiparkinsonian benefit or worsen psychosis. Sedation and dizziness can also add up.
How serious is the interaction between Cariprazine and Entacapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptoms and psychiatric status when the combination is started or adjusted. Advise on sedation and orthostatic dizziness, and review the antipsychotic choice if parkinsonism worsens.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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