Drug interactions
Cariprazine + Flibanserin
Severity: Moderate
Cariprazine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and hypotension, so combined use may add to drowsiness and dizziness. Serotonergic and neuroleptic malignant syndrome-like effects are theoretically possible given overlapping receptor activity.
What this interaction means in plain words
Cariprazine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive CNS depression and overlapping serotonergic and dopaminergic receptor effects.
What to do
Monitor for sedation, hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Counsel about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Flibanserin?
MediHelp rates the interaction as moderate. Cariprazine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and hypotension, so combined use may add to drowsiness and dizziness. Serotonergic and neuroleptic malignant syndrome-like effects are theoretically possible given overlapping receptor activity.
How serious is the interaction between Cariprazine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension, and signs of serotonin toxicity or neuroleptic malignant syndrome. Counsel about driving and alcohol.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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