Drug interactions
Cariprazine + Haloperidol
Severity: Moderate
Cariprazine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antipsychotics that cause sedation and extrapyramidal effects, so combined use increases the risk of drowsiness, akathisia, parkinsonism and neuroleptic malignant syndrome. Antipsychotic polypharmacy adds adverse effects without clear benefit.
What this interaction means in plain words
Cariprazine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Additive dopamine receptor antagonism or partial agonism and CNS depression.
What to do
Avoid combining where possible. If necessary, monitor for sedation and extrapyramidal symptoms and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Haloperidol?
MediHelp rates the interaction as moderate. Cariprazine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antipsychotics that cause sedation and extrapyramidal effects, so combined use increases the risk of drowsiness, akathisia, parkinsonism and neuroleptic malignant syndrome. Antipsychotic polypharmacy adds adverse effects without clear benefit.
How serious is the interaction between Cariprazine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If necessary, monitor for sedation and extrapyramidal symptoms and use the lowest effective doses.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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