Drug interactions
Cariprazine + Hydroxyzine
Severity: Moderate
Cariprazine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine with anticholinergic properties and cariprazine can cause somnolence. Combined use may cause marked drowsiness and impaired psychomotor performance. Hydroxyzine has also been associated with QT prolongation, which adds a cardiac consideration in vulnerable patients.
What this interaction means in plain words
Cariprazine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive central nervous system depression from H1 antagonism and antipsychotic effects.
What to do
Use the lowest effective hydroxyzine dose and warn about sedation and driving. Consider an ECG and electrolyte check in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Cariprazine with Hydroxyzine?
MediHelp rates the interaction as moderate. Cariprazine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine with anticholinergic properties and cariprazine can cause somnolence. Combined use may cause marked drowsiness and impaired psychomotor performance. Hydroxyzine has also been associated with QT prolongation, which adds a cardiac consideration in vulnerable patients.
How serious is the interaction between Cariprazine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose and warn about sedation and driving. Consider an ECG and electrolyte check in patients with other QT risk factors.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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