Drug interactions
Cariprazine + Iloperidone
Severity: Moderate
Cariprazine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics, so combining them duplicates therapy and adds to sedation, orthostatic hypotension and extrapyramidal effects. Iloperidone also prolongs the QT interval, which adds a cardiac concern.
What this interaction means in plain words
Cariprazine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Additive dopamine and serotonin receptor antagonism, CNS depression and QT effects (pharmacodynamic).
What to do
Avoid routine antipsychotic polytherapy where possible. If combined, monitor sedation, blood pressure, motor symptoms and ECG with correction of electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Cariprazine with Iloperidone?
MediHelp rates the interaction as moderate. Cariprazine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics, so combining them duplicates therapy and adds to sedation, orthostatic hypotension and extrapyramidal effects. Iloperidone also prolongs the QT interval, which adds a cardiac concern.
How serious is the interaction between Cariprazine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine antipsychotic polytherapy where possible. If combined, monitor sedation, blood pressure, motor symptoms and ECG with correction of electrolytes.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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