Drug interactions
Cariprazine + Levomilnacipran
Severity: Moderate
Cariprazine and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran increases serotonin and norepinephrine, and cariprazine acts on serotonin and dopamine receptors. The combination carries a theoretical risk of serotonin syndrome or neuroleptic malignant syndrome, though this is uncommon and antipsychotics are often combined with antidepressants.
What this interaction means in plain words
Cariprazine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic and dopaminergic effects (pharmacodynamic).
What to do
Monitor for agitation, tremor, hyperreflexia, hyperthermia, rigidity and autonomic instability, especially after dose changes. Stop the drugs and give supportive care if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Cariprazine with Levomilnacipran?
MediHelp rates the interaction as moderate. Cariprazine and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran increases serotonin and norepinephrine, and cariprazine acts on serotonin and dopamine receptors. The combination carries a theoretical risk of serotonin syndrome or neuroleptic malignant syndrome, though this is uncommon and antipsychotics are often combined with antidepressants.
How serious is the interaction between Cariprazine and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, hyperthermia, rigidity and autonomic instability, especially after dose changes. Stop the drugs and give supportive care if toxicity emerges.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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