Drug interactions
Cariprazine + Lonafarnib
Severity: Major
Cariprazine and Lonafarnib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A4 inhibitor and can substantially raise cariprazine exposure. This may increase adverse effects such as akathisia, parkinsonism and sedation, and the effect is prolonged by the long-lived metabolites.
What this interaction means in plain words
Cariprazine and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cariprazine.
What to do
Reduce the cariprazine dose in line with its labeling for strong CYP3A4 inhibitors and monitor for adverse effects. Reassess the dose after lonafarnib is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cariprazine
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Cariprazine with Lonafarnib?
MediHelp rates the interaction as major. Cariprazine and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a strong CYP3A4 inhibitor and can substantially raise cariprazine exposure. This may increase adverse effects such as akathisia, parkinsonism and sedation, and the effect is prolonged by the long-lived metabolites.
How serious is the interaction between Cariprazine and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cariprazine dose in line with its labeling for strong CYP3A4 inhibitors and monitor for adverse effects. Reassess the dose after lonafarnib is discontinued.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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