Drug interactions
Cariprazine + Lurasidone
Severity: Moderate
Cariprazine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases the overall burden of sedation, extrapyramidal symptoms, metabolic effects and orthostatic hypotension. Cariprazine and lurasidone are both CYP3A4 substrates, but there is no major pharmacokinetic interaction between them. Antipsychotic polypharmacy is usually reserved for cases that have not responded to monotherapy.
What this interaction means in plain words
Cariprazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from combined dopamine, serotonin and adrenergic receptor antagonism or partial agonism.
What to do
Use the combination only when clearly justified, with the lowest effective doses. Monitor for sedation, akathisia, parkinsonism, blood pressure and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Cariprazine with Lurasidone?
MediHelp rates the interaction as moderate. Cariprazine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases the overall burden of sedation, extrapyramidal symptoms, metabolic effects and orthostatic hypotension. Cariprazine and lurasidone are both CYP3A4 substrates, but there is no major pharmacokinetic interaction between them. Antipsychotic polypharmacy is usually reserved for cases that have not responded to monotherapy.
How serious is the interaction between Cariprazine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination only when clearly justified, with the lowest effective doses. Monitor for sedation, akathisia, parkinsonism, blood pressure and metabolic parameters.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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