Drug interactions
Cariprazine + Meperidine
Severity: Moderate
Cariprazine and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so sedation and psychomotor impairment may be greater than with either alone. Meperidine is also serotonergic, and antipsychotics with serotonin receptor activity may add to the risk of serotonin toxicity. Dopamine blockade may rarely contribute to neuroleptic malignant syndrome.
What this interaction means in plain words
Cariprazine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression plus overlapping serotonergic and dopaminergic effects.
What to do
Start with lower doses and monitor for excess sedation, respiratory depression, and signs of serotonin toxicity such as agitation, clonus, and hyperthermia. Stop the drugs and treat if rigidity or fever develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Meperidine?
MediHelp rates the interaction as moderate. Cariprazine and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so sedation and psychomotor impairment may be greater than with either alone. Meperidine is also serotonergic, and antipsychotics with serotonin receptor activity may add to the risk of serotonin toxicity. Dopamine blockade may rarely contribute to neuroleptic malignant syndrome.
How serious is the interaction between Cariprazine and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses and monitor for excess sedation, respiratory depression, and signs of serotonin toxicity such as agitation, clonus, and hyperthermia. Stop the drugs and treat if rigidity or fever develops.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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