Drug interactions
Cariprazine + Midazolam
Severity: Moderate
Cariprazine and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine may cause somnolence and orthostatic effects. With midazolam, sedation and impaired psychomotor function may be increased.
What this interaction means in plain words
Cariprazine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of a benzodiazepine and an antipsychotic.
What to do
Use cautious midazolam titration and monitor sedation and blood pressure. Counsel patients to avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Midazolam?
MediHelp rates the interaction as moderate. Cariprazine and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine may cause somnolence and orthostatic effects. With midazolam, sedation and impaired psychomotor function may be increased.
How serious is the interaction between Cariprazine and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use cautious midazolam titration and monitor sedation and blood pressure. Counsel patients to avoid driving.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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