Drug interactions
Cariprazine + Paliperidone
Severity: Moderate
Cariprazine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two antipsychotics together increases the risk of sedation, orthostatic hypotension, extrapyramidal symptoms, QT effects and metabolic disturbances. Paliperidone is mainly renally eliminated, so no significant pharmacokinetic interaction with cariprazine is expected.
What this interaction means in plain words
Cariprazine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Paliperidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from combined dopamine and serotonin receptor modulation.
What to do
Use combination only when monotherapy has failed, at the lowest effective doses. Monitor for movement disorders, sedation, blood pressure and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Cariprazine with Paliperidone?
MediHelp rates the interaction as moderate. Cariprazine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two antipsychotics together increases the risk of sedation, orthostatic hypotension, extrapyramidal symptoms, QT effects and metabolic disturbances. Paliperidone is mainly renally eliminated, so no significant pharmacokinetic interaction with cariprazine is expected.
How serious is the interaction between Cariprazine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use combination only when monotherapy has failed, at the lowest effective doses. Monitor for movement disorders, sedation, blood pressure and metabolic parameters.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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