Drug interactions
Cariprazine + Perphenazine
Severity: Moderate
Cariprazine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics can cause sedation and extrapyramidal symptoms, so combining them may increase drowsiness, akathisia and parkinsonism. Perphenazine may also modestly raise cariprazine exposure via CYP2D6 inhibition.
What this interaction means in plain words
Cariprazine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopamine D2 antagonism.
What to do
Use the lowest effective doses and monitor for sedation, akathisia and other movement disorders. Prefer antipsychotic monotherapy if clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Perphenazine?
MediHelp rates the interaction as moderate. Cariprazine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both antipsychotics can cause sedation and extrapyramidal symptoms, so combining them may increase drowsiness, akathisia and parkinsonism. Perphenazine may also modestly raise cariprazine exposure via CYP2D6 inhibition.
How serious is the interaction between Cariprazine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, akathisia and other movement disorders. Prefer antipsychotic monotherapy if clinically feasible.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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