Drug interactions
Cariprazine + Promethazine
Severity: Moderate
Cariprazine and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is a phenothiazine with dopamine-blocking and sedative properties, so combining it with cariprazine adds to sedation and extrapyramidal effects. It may also modestly increase the risk of QT effects and, rarely, neuroleptic malignant syndrome.
What this interaction means in plain words
Cariprazine and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive dopamine D2 receptor antagonism and CNS depression.
What to do
Monitor for sedation, extrapyramidal symptoms and signs of neuroleptic malignant syndrome such as fever and rigidity. Use the lowest effective promethazine dose and limit duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Cariprazine with Promethazine?
MediHelp rates the interaction as moderate. Cariprazine and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine is a phenothiazine with dopamine-blocking and sedative properties, so combining it with cariprazine adds to sedation and extrapyramidal effects. It may also modestly increase the risk of QT effects and, rarely, neuroleptic malignant syndrome.
How serious is the interaction between Cariprazine and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and signs of neuroleptic malignant syndrome such as fever and rigidity. Use the lowest effective promethazine dose and limit duration.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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