Drug interactions
Cariprazine + Ribociclib
Severity: Moderate
Cariprazine and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and can raise exposure to cariprazine and its active metabolites, which are cleared mainly by CYP3A4. Higher exposure may increase adverse effects such as akathisia, sedation and extrapyramidal symptoms. Ribociclib also prolongs the QT interval, which adds a separate concern.
What this interaction means in plain words
Cariprazine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolism of cariprazine and its active metabolites.
What to do
Monitor for increased cariprazine adverse effects, and consider a dose reduction if they emerge. Obtain an ECG and check electrolytes at baseline and during treatment, as ribociclib prolongs QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Cariprazine with Ribociclib?
MediHelp rates the interaction as moderate. Cariprazine and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and can raise exposure to cariprazine and its active metabolites, which are cleared mainly by CYP3A4. Higher exposure may increase adverse effects such as akathisia, sedation and extrapyramidal symptoms. Ribociclib also prolongs the QT interval, which adds a separate concern.
How serious is the interaction between Cariprazine and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased cariprazine adverse effects, and consider a dose reduction if they emerge. Obtain an ECG and check electrolytes at baseline and during treatment, as ribociclib prolongs QT.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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