Drug interactions
Cariprazine + Temazepam
Severity: Moderate
Cariprazine and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so concurrent use can increase drowsiness, dizziness and psychomotor impairment. Falls and impaired alertness are of particular concern in older patients.
What this interaction means in plain words
Cariprazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cariprazine belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects via antagonism of histaminergic and other receptors by cariprazine and GABA-A potentiation by temazepam.
What to do
Use the lowest effective temazepam dose and counsel patients about driving and fall risk. Monitor sedation, especially after dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Cariprazine with Temazepam?
MediHelp rates the interaction as moderate. Cariprazine and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so concurrent use can increase drowsiness, dizziness and psychomotor impairment. Falls and impaired alertness are of particular concern in older patients.
How serious is the interaction between Cariprazine and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose and counsel patients about driving and fall risk. Monitor sedation, especially after dose increases.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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