Drug interactions
Cariprazine + Tipranavir
Severity: Major
Cariprazine and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir given with ritonavir has net strong CYP3A4 inhibiting effect, which can increase cariprazine and metabolite exposure. This increases the risk of dose-related adverse effects such as akathisia and sedation.
What this interaction means in plain words
Cariprazine and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4, reducing cariprazine clearance.
What to do
Lower the cariprazine dose according to labeling for strong CYP3A4 inhibitors and monitor closely for adverse effects. Re-titrate when the protease inhibitor is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cariprazine
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Cariprazine with Tipranavir?
MediHelp rates the interaction as major. Cariprazine and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir given with ritonavir has net strong CYP3A4 inhibiting effect, which can increase cariprazine and metabolite exposure. This increases the risk of dose-related adverse effects such as akathisia and sedation.
How serious is the interaction between Cariprazine and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Lower the cariprazine dose according to labeling for strong CYP3A4 inhibitors and monitor closely for adverse effects. Re-titrate when the protease inhibitor is stopped.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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